To solve the problem of preserving detailed features of model about the traditional skeleton driven deformation, a method of subdivision-based skeleton-driven mesh deformation was proposed. Firstly,after that skeleton and control mesh were generated on deformed region, the relationship of between skeleton and control mesh, subdivision surface of control mesh and deformed region were established. Secondly, when the skeleton was modified according to the desired deformation result, the change information of the corresponding subdivision surface was transformed into the alteration of the mesh gradient field for Poisson. Some examples show that the deformation method for different mesh models could get better editing effects and preserve detailed features after the deformation effectively. Compared with the traditional skeleton-driven deformation method, it is proved to be easy to operate, and can be employed to preserve detailed features effectively. The method is suitable for editing the models with complex and rich geometric details.